Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | GTPCH expression is regulated by inflammatory stimuli, in association with reduced expression of GTP cyclohydrolase feedback regulatory protein | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | GTP cyclohydrolase feedback regulatory protein overexpression and knockdown in tet-GCH cells does not alter GTPCH activity or tetrahydrobiopterin levels, and GTPCH-specific knockdown in sEnd.1 endothelial cells has no effect on GTP cyclohydrolase feedback regulatory protein | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
NIH-3T3 cell | transfected with a tet-off plasmid and a plasmid encoding human GCH1, the stable clone is named tet-GCH cell | Mus musculus | - |
sEnd-1 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GTP cyclohydrolase I | - |
Mus musculus |
GTPCH | - |
Mus musculus |